Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies ( 4.5 Asthma Asthma is a very common chronic lung disease characterized by chronic persistent airway inflammation and airway remodeling, resulting in incompletely reversible airway obstruction, especially in advanced stages ( 5 Discussion The safety and efficacy of GLP-1RAs in the treatment of type 2 diabetes have been well demonstrated
Here, we analyzed the small intestine transcriptome of geniposide, a recognized small-molecule GLP-1R agonist, and identified that cinchonine exerted GLP-1R agonist-like effects using CMap
Inflammation plays a critical role in wound-healing
Aerotolerance and peroxide resistance in peroxidase and PerR mutants of streptococcus pyogenes
However, studies have shown that periods of intense exercise and heavy lifting, seen in athletes, are associated with a decrease in plasma glutamine concentrations which could result in a demand outweighing supply in the body
